Milan Mrksich: Synthesis and applications of MegaMolecules
YUCOMAT 2023
Prof Dr Yury Gogotsi.
YUCOMAT 2023
Nemanja Barac, Vukašin Ugrinović, Jovan Lukić, Veljko Đokić, Željko Radovanović, Tamara Matić, Jana Petrovicć
YUCOMAT 2023
Audience
YUCOMAT 2023
Audience
YUCOMAT 2023
Herceg Novi, Montenegro, 2023
YUCOMAT 2023
YUCOMAT 2023
Herceg Novi, Montenegro, 2023
YUCOMAT 2023
Herceg Novi, Montenegro, 2023
YUCOMAT 2023
Herceg Novi, Montenegro, 2023
YUCOMAT 2023
Herceg Novi, Montenegro, 2023
YUCOMAT 2023
YUCOMAT 2023
prof Dragan Uskokovic, prof Yury Gogotsi, prof Knut Urban MRS Serbia award
YUCOMAT 2023
prof Petar Uskokovic YUCOMAT AWARDS, Ievgen Solodky
YUCOMAT 2023
Herceg Novi, Montenegro, 2023
YUCOMAT 2023
Herceg Novi, Montenegro, 2023
YUCOMAT 2023
best oral presentations awardees
YUCOMAT 2023
Prof dr Mario Ferreira
YUCOMAT 2023
prof dr Maksym Pogorielov and prof dr Yury Gogotsi
YUCOMAT 2023
Prof dr Markus Antonietti discussion.
YUCOMAT 2023
prof dr Dongyuan Zhao lecture discussion
YUCOMAT 2023
Herceg Novi, Montenegro
YUCOMAT 2023
Herceg Novi, Montenegro
YUCOMAT 2023
Herceg Novi, Montenegro
YUCOMAT 2023
audience
YUCOMAT 2023
prof dr Vladimir Torchilin, prof dr Samuel Stupp
YUCOMAT 2023
Herceg Novi, Montenegro
YUCOMAT 2023
Tamara Matić lecture discussion
YUCOMAT 2023
Herceg Novi, Montenegro
YUCOMAT 2023
Herceg Novi, Montenegro

Milan Mrksich

 

Department of Biomedical Engineering and Chemistry, Northwestern University  This email address is being protected from spambots. You need JavaScript enabled to view it.

 

This talk will describe an approach for synthesizing molecules that have sizes greater than 100 nm and yet are structurally perfectly defined. The approach relies on the selective and covalent reaction of an enzyme domain with an irreversible linker. Fusion proteins containing two or more of the enzyme domains are treated with linkers terminated in two or more of the irreversible inhibitors, leading to the rapid reaction of the partners and efficient assembly of the megamolecule. Several enzyme-inhibitor pairs have been developed, and used to prepare megamolecules that are linear, cyclic, branched, and that have molecular weights greater than 500,000 Dalton, and sizes greater than 100 nm (Figure 1). The talk will describe the use of this approach to create synthetic antibodies for therapeutic applications, and outline routes to a broad array of functional molecules.

Mrksic
Figure 1. Megamolecules are prepared by reacting fusion proteins with molecular linkers that assemble by way of reactions of irreversible inhibitors with specific enzyme domains. Examples of megamolecules that can be assembled include linear structures (top), cyclic structures (left) and branched structures (right).

The megamolecules offer new approaches for preparing scaffolds that can spatially organize protein domains. This talk will describe the assembly of synthetic antibodies that position two (or more) Fab domains with control over the distance and orientation of the domains, as well as bispecific antibodies that present two distinct Fab domains. The talk will include a discussion of applications of this method to prepare nanoscale membranes having biological functions.

Plenary lectures - YUCOMAT 2019

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